With the loss the Tigers fall to 19-8 overall and 7-6 in conference play.
Clemson built a 15-point lead after a hot shooting start that saw the Tigers connect on eight three pointers in the first half.
"Our guys were ready and energetic but we've won games shooting 30 percent," Clemson head basketball coach Oliver Purnell said. "Tonight we had plenty of offense but when you let Maryland shoot 60 percent (in the second half) it finally caught up for us."
A late 7-0 run helped Maryland cut the lead to nine shortly before halftime before the Terps then took control in the second half courtesy of a 37-15 run.
Clemson made just 3-of-14 from behind the arc in the second half as Maryland, led by All-ACC guard Greivis Vasquez rallied for the win.
"We had a little bit of fool's gold that came back to haunt us," Purnell said. "We didn't have the defensive mindset we needed. It kind of left us midway through the first half because we were scoring so much."
Clemson was led in scoring by Demontez Stitt, who finished with 15 points. Trevor Booker and David Potter both added 13.
Both Booker and Potter scored 11 in the first half before scoring just two-points apiece in the second.
Jerai Grant, who scored a career high 18 points against Maryland in Clemson's nine-point win at Littlejohn last month, played just 10 minutes and finished scoreless after fouling out early in the second half.
"That was critical," Purnell said of Grant's absence. "They took advantage against our younger guys in the post. They were able to throw the ball into the post at will."
Sean Mosley scored 20 points off the bench to lead Maryland, while Greivis Vasquez had 15 points and 13 assists.
Vasquez drilled a three pointer from the right wing to put Maryland ahead 70-67 with 7:24 remaining in the game.
It was the first lead for the Terps since the score was 14-12 early in the first half.
Jordan Williams followed with a layup and Eric Hayes added a 3-pointer before Vasquez capped the spree with a steal and a dunk to make it 77-67 with 6:04 remaining.
The Tigers closed within five points in the final minutes but never got closer.
"We didn't do well in the final six minutes but we didn't do well tonight at all defensively," Purnell added.
With the win, the Terrapins (20-7, 10-3) improved to 14-1 at home, including 7-0 in the ACC.
Jason Williams scored 18 and Eric Hayes added 15 for Maryland, which solidified its hold on second place in the Atlantic Coast Conference.
Clemson, which is now in sixth place in the ACC after Wednesday night's loss, returns to action Sunday afternoon at Florida State.
Tip-off is set for 5:30 PM.
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